Sakeen Kashem, MD, PhD

Regulatory T cell-derived enkephalin gates nociception.

Midavaine É, Moraes BC, Benitez J, Rodriguez SR, Braz JM, Kochhar NP, Eckalbar WL, Domingos AI, Pintar JE, Basbaum AI, Kashem SW PMID: 38798460

Discovery of a CCR2-targeting pepducin therapy for chronic pain.

Midavaine É, Brouillette RL, Théberge E, Mona CE, Kashem SW, Côté J, Zeugin V, Besserer-Offroy É, Longpré JM, Marsault É, Sarret P PMID: 38823470

Neuropeptide substance P alters stem cell fate to aid wound healing and promote epidermal stratification through asymmetric stem cell divisions.

Khalifa A, Xiao T, Abegaze B, Weisenberger T, Charruyer A, Sanad S, AbuElnasr T, Kashem SW, Fassett M, Ghadially R PMID: 38301639

Can Serum Biomarkers for Prurigo Nodularis Expose Pathophysiology or Just Treatment Response?

Kashem SW, Fassett MS PMID: 37556170

Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch

Crowther AJ, Kashem SW, Jewell ME, Chang HL, Casillas MR, Midavaine E, Rodriguez S, Braz JM, Kania A, Basbaum AI PMID:

Spontaneous resolution of intractable prurigo nodularis after subinsular cortex stroke.

Kashem SW, Motzkin JC, Leslie KS PMID: 36687303

Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells.

Whitley SK, Li M, Kashem SW, Hirai T, Igyártó BZ, Knizner K, Ho J, Ferris LK, Weaver CT, Cua DJ, McGeachy MJ, Kaplan DH PMID: 36367947

A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity.

Cook CP, Taylor M, Liu Y, Schmidt R, Sedgewick A, Kim E, Hailer A, North JP, Harirchian P, Wang H, Kashem SW, Shou Y, McCalmont TC, Benz SC, Choi J, Purdom E, Marson A, Ramos SBV, Cheng JB, Cho RJ PMID: 35977472

Association of Facial Pustular Neutrophilic Eruption With Messenger RNA-1273 SARS-CoV-2 Vaccine.

Merrill ED, Kashem SW, Amerson EH, Pincus LB, Lang UE, Shinkai K, Chang AY PMID: 34319363

Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation.

Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC, Ghadially R, Mauro TM, Kaplan DH, Kabashima K, Choi J, Song JS, Cho RJ, Cheng JB PMID: 33205009