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| Training |
- MD/PhD: Duke University
- Residency: Department of Dermatology, University of California, San Francisco
- Fellowship: Department of Biochemistry and Biophysics, University of California, San Francisco
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| Clinical Specialties |
Research Interests |
- Pigment Disorders
- General Dermatology
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- Melanocyte Biology
- Melanosome Biogenesis
- Genetic Disorders of Pigmentation/Oculocutaneous Albinism
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| Dr. Wei's laboratory studies melanocyte biology, with
a special interest in genetic disorders of pigmentation such as
Hermansky-Pudlak Syndrome (HPS) and Chediak-Higashi Syndrome (CHS).
These recessive autosomal syndromes present clinically as multisystem disorders, affecting
vision, bleeding time, immune function (CHS), lung and colon function
(HPS), as well as causing pigment dilution. HPS and CHS are caused
by single gene defects that affect organelle biogenesis and maturation in specialized
cells, however the exact function of HPS and CHS genes is unknown.
Dr Wei's lab uses a combination of cell biological, molecular biology,
and morphologic techniques to analyze the function of HPS and CHS
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| Key Publications |
- Akarsu S, Gurgoze MK, Ocal C, Sen Y, Aygun AD, Wei ML. Association of oculocutaneous albinism and osteopetrosis. (in preparation)
- Nguyen T, Wei ML. 2007. Hermansky-Pudlak: HPS1/pale ear gene regulates epidermal and dermal melanocyte development. Journal of Investigative Dermatology Feb;127(2): 421-8. Epub 2006 Oct 19.
- Wei ML. 2006. Hermansky-Pudlak Syndrome: A disease of protein trafficking and organelle function. Pigment Cell Research Journal 19(1):19-42.
- Nguyen T, Wei ML. 2004. Characterization of melanosomes in murine Hermansky-Pudlak Syndrome: Mechanisms of hypopigmentation. Journal of Investigative Dermatology 122(2): 452-60.
- Nguyen T, Novak ET, Kermani M, Fluhr J, Peters LL, Swank RT, Wei ML. 2002. Melanosome morphologies in murine
models of Hermansky-Pudlak Syndrome reflect blocks in organelle
development. Journal of Investigative Dermatology 119(5):
1156-64.
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