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| Contact Information |
(415) 476-7927 phone
(415) 476-8677 fax
connolly@derm.ucsf.edu |
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| Training |
- MD: Albany Medical College
- Residency: University of California, Los Angeles
Internal Medicine
- Residency: University of California, San Francisco
Dermatology
- Fellowship: University of California, San Francisco
Rheumatology
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| Clinical Specialties and Research Interests |
- Autoimmune Skin Diseases
- Lupus Erythematosus
- Dermatomyositis
- Scleroderma
- Blistering Diseases
- New Biologic Agents in Autoimmune Diseases
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Dr. Connolly's overall interest is in autoimmune skin diseases
and the mechanisms by which tissue damage occurs. She is involved
with a variety of research studies involving lupus erythematosus,
dermatomyositis, scleroderma and blistering diseases. Her laboratory
processes several hundred specimens a year. She participates in
a variety of clinical trials looking at new biologic agents in
autoimmune diseases.
Dr. Connolly's primary research focus is on the mechanisms of
disease in scleroderma skin. The centerpiece of this project is
the UCSF Scleroderma Database and Tissue Bank. This collaborative
effort combines clinical data and tissue specimens with basic
science tools to generate new molecular markers for scleroderma.
The goal is to analyze these samples using increasingly sophisticated
microarrays and bioinformatics programs. Dr. Connolly has begun
this analysis for sets of expressed gene products in scleroderma
skin and fibroblasts and sees this as an important new approach
to address fundamental questions in this disease. The scope of
these projects is broad and encompasses the immune system, growth
factors and their receptors, the extracellular matrix, blood vessles
and nerves in the skin in order to advance the understanding and
treatment of scleroderma. |
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| Recent Publications |
- Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shiwen
X, Chen Y, Venstrom K, Dou X, Ponticos M, Jackman JK, Findell
PR, Connolly MK. Dysregulation of TGFß
signaling in scleroderma: Over-expression of endoglin in cutaneous
scleroderma fibroblasts. Arthritis Rheum 2002, 46:1857-1865.
- O'Hare A, Olson JL, Connolly MK, Ward JW,
Stein P, Wisnieski JJ, Chertow GM. Renal insufficiency with
monoclonal gammopathy and urticarial vasculitis. Am J Kidney
Dis 2002, 39:203-207.
- Connolly MD, Tuffanelly DL. Systemic sclerosis.
In: Cutaneous Manifestation of Rheumatic Diseases. (eds)
RD Sontheimer, TT Provost. 2nd edition. Williams & Wilkins,
Baltimore, MD, (in press), 2003.
- Whitfield ML, Finlay DR, Murray JI, Troyanskaya OG, Chi JT,
Pergamenschikov A, Brown PO, Botstein D, Connolly MK.
Gene expression patterns in scleroderma. PNAS (manuscript submitted),
2003.
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